NLRP3 and head and neck squamous cell carcinoma: Based on this, the NLRP3 (nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat-containing receptors (NLRs) family pyrin domain containing 3) is one of the best-described inflammasome proteins, and EVs isolated from HNSCC patients, which were enriched in TGF-β signaling molecules, were able to inhibit the induction of pro-IL-1β and pro-caspase-1 proteins, in addition to the downregulation of NLRP3 expression during the priming phase of inflammasome activation (Bottino et al., 2021).