For instance, TGFBR2 deficiency that inactivates most if not all aspects of TGF-β signaling, affects the miRNA and protein content of EVs derived by colorectal cancer (CRC) cells, indicating that TGF-β signaling may regulate EV biogenesis or secretion (Fricke et al., 2019a; Fricke et al., 2019b). Here, TGFB1 is linked to colorectal cancer.