TGFB1 and lung adenocarcinoma: In addition, EVs derived from lung adenocarcinoma cell lines increased proliferation of pre-neoplastic bronchial epithelial cells, favoring tumor growth, due to the transfer of miR-19b and miR-92a, which attenuated the expression of TGFBRI and TGFBRII in the recipient epithelial cells, where the anti-proliferative role of TGF-β is well established (Borzi et al., 2019).