RUNX3 and c-MYC form complexes on the regulatory sequences of the TGFB1 gene and RUNX3 suppresses the transcriptional activity of c-MYC, which positively induces expression of TGF-β1, the latter promoting CRC cell invasiveness; thus, when CAFs secrete their EVs, they provide miR-17-5p to CRC cells, negatively regulating RUNX3 and consequently de-repressing the TGFB1 gene via c-MYC. This evidence concerns the gene TGFB1 and colorectal carcinoma.