TGFB1 and colorectal carcinoma: In colorectal carcinoma, TGF-β1 was found to upregulate miR-200b levels; transfer of miR-200b to recipient cells via EVs directly targeted the 3′- UTR of the p27 mRNA, suppressing expression of this cell cycle inhibitor, and leading to increased cancer cell proliferation (Zhang et al., 2018).