Moreover, EVs isolated from esophageal cancer (ECA) cells carrying lysosomal associated membrane protein 1 (LAMP1) and MMP-9 induced naive B cells to differentiate into TGF-β-producing regulatory B cells (Table 1), which led to immunosuppressive effects on CD8+ T-cells (Li et al., 2015). The gene discussed is LAMP1; the disease is esophageal cancer.