Colorectal carcinomas secrete EVs carrying the non-coding RNA circPACRGL that regulates the expression of TGF-β by binding to miR-142-3p and miR-506-3p, promoting cancer cell proliferation and metastasis, mediated by the transformation of N1 neutrophils to N2 in the TME (Shang et al., 2020). This evidence concerns the gene TGFB1 and cancer.