TGFB1 and melanoma: Furthermore, PS presented on EVs isolated from B16F10 malignant murine melanoma cells, elicited anti-inflammatory responses on macrophages by inducing TGF-β1 secretion and enhancing the metastatic potential of B16F10 cells in C57BL/6 mice, while these effects were abrogated when the PS on EVs was blocked with annexin V (Lima et al., 2009).