Moreover, EVs derived from TGFB1-silenced leukemic cells, promoted DC activation, facilitated CD4+ T-cell proliferation and Th1 cytokine secretion, and further stimulated cytotoxic responses in lymphocytes and NK cells when compared to the control leukemia-EVs (Huang et al., 2017). This evidence concerns the gene TGFB1 and leukemia.