As discussed in the tumorigenesis section, EVs from breast or prostate carcinoma cells that carry TGF-β and TGFβRIII co-receptor on their surface, induced stromal fibroblast to myofibroblast differentiation with strong αSMA expression (Webber et al., 2010; Webber et al., 2015). The gene discussed is ACTA1; the disease is prostate carcinoma.