TGFB1 and colorectal carcinoma: In these two examples, downregulation of TGFβRIII is thought to inhibit physiological TGF-β signaling, which acts homeostatically, and thus, the loss of the co-receptor TGFβRIII might be equivalent to the loss-of-function mutations in TGFβRII that sometimes are required for the progression of CRC.