For instance, TGFBR2 deficiency that inactivates most if not all aspects of TGF-β signaling, affects the miRNA and protein content of EVs derived by colorectal cancer (CRC) cells, indicating that TGF-β signaling may regulate EV biogenesis or secretion (Fricke et al., 2019a; Fricke et al., 2019b). This evidence concerns the gene TGFB1 and colorectal carcinoma.