Thus, EVs secreted from CAFs act on CRC cells, causing de-repression and expression of TGF-β3, via the action of miR-93-5p on FOXA1; the increased amounts of TGF-β3 contributed to the proliferation after escape from apoptosis that was induced by radiation (Chen et al., 2020). Here, TGFB3 is linked to colorectal carcinoma.