Furthermore, mast cell-derived EVs rich in TGF-β1 on their surface, induced EMT when taken up by epithelial human lung adenocarcinoma cells as observed by increased mRNA and protein levels of EMT-TFs (TWIST1, SNAI1, SNAI2) and of induced phosphorylation of cellular proteins involved in EMT (TGM2, annexin-A1, VACM1, Chrombox3), cell-cell junctions (E-cadherin, N-cadherin), cell-ECM interactions (MMP-2, MMP-9) and cell proliferation (c-KIT) (Yin et al., 2020). Here, TGFB1 is linked to lung adenocarcinoma.