Moreover, glioma cell-derived exosomal lncRNA activated by TGF-β (lncRNA-ATB) suppresses miR-204-3p in an argonaute 2-dependent manner in recipient astrocytes, causing activation of migration and invasion of glioma cells by induction of TGF-β signaling (Bian et al., 2019). This evidence concerns the gene TGFB1 and central nervous system cancer.