Additionally, the increased CCN2/CTGF levels in the periphery of the glaucomatous human ON, but not the central part supports the finding that the lamina cribrosa strains were larger in the peripheral lamina cribrosa compared to the central lamina cribrosa, and lamina cribrosa strains in the more severely damage glaucoma group were larger than those in the more mildly damaged group and larger differences were measured between peripheral and central lamina cribrosa strains in the more severely damaged glaucoma group (Midgett et al., 2020). Here, CCN2 is linked to glaucoma.