An upregulation of CCN2/CTGF was observed in reactive astrocytes during other neurodegenerative diseases like multiple sclerosis (Holley et al., 2003), amyotrophic lateral sclerosis (Spliet et al., 2003) and Alzheimer’s disease (Ueberham et al., 2003). This evidence concerns the gene CCN2 and early-onset autosomal dominant Alzheimer disease.