As shown in HCT 116 colon cancer cells, the K-Ras gene induces uPAR transcription through the binding of c-Jun, JunD, c-Fos and Fra-1 to the AP-1 motif in the uPAR promoter at –184 (Allgayer et al., 1999a). Here, PLAUR is linked to malignant colon neoplasm.