In human HEp3 squamous cell carcinoma growth in vivo, the extent of uPAR/αvß5 physical association is important to maintain high levels of ERK1/2 activity, whereas the inhibition of uPAR expression leads to a reduced complex formation and tumour dormancy (Aguirre Ghiso et al., 1999). This evidence concerns the gene PLAUR and squamous cell carcinoma.