PLAUR and medulloblastoma: Asuthkar et al. showed that in the UW228 and D283 medulloblastoma cell lines, uPAR overexpression leads to increased WNT-7a-β-catenin-TCF/LEF-mediated transactivation whereas uPAR silencing has an opposite effect, uncovering a mutual regulatory relationship between uPAR and WNT/β-catenin signalling (Asuthkar et al., 2012).