More recently, Carriero’s group showed that the association of uPAR with the overexpressed FPR1 leads to the melanoma and ovarian cancer cell invasion, that is inhibited by the potent RI-3 peptide, disrupting the uPAR84–95/FPR1 interaction (Ragone et al., 2017; Minopoli et al., 2019). Here, PLAUR is linked to melanoma.