The combined silencing of uPAR and cathepsin B in CD133 + TICs leads to the dissociation of pPKC θ/δ, integrin β1 and PKC ζ, integrin β1 complex as well as the dissociation of FAK, vinculin and α-actinin, thus inhibiting PKC/integrin signalling, and ultimately controlling GBM tumor invasion and resistance (Alapati et al., 2012). Here, PLAUR is linked to glioblastoma.