PROM1 and hepatocellular carcinoma: Hepatocellular carcinoma cell lines expressing high levels of CD133+, exhibit a concomitant upregulation of invasion-associated genes like uPAR, MMP1, MMP2, and EMT regulators like Snail and Twist, suggesting that the expression of CD133+ is associated to a subtype of aggressive hepatocellular carcinoma (Na et al., 2011).