Consistent with this, a chemical activator of cholesterol 24-hydroxylase (CYP46A1) increased 24-hydroxycholesterol secretion from APP mutant iPSC-derived neurons (but not astrocytes) lowering CEs and increasing proteosomal degradation of phosphorylated Tau, a hallmark of Alzheimer’s Disease (van der Kant et al., 2019). This evidence concerns the gene CYP46A1 and early-onset autosomal dominant Alzheimer disease.