In the case of LD lipolysis, recessive mutations in a brain TAG lipase (DDHD Domain-Containing 2 (DDHD2)), which hydrolyzes LD core lipids, underlie a form of complex hereditary spastic paraplegia (Schuurs-Hoeijmakers et al., 2012; Inloes et al., 2018). The gene discussed is DDHD2; the disease is hereditary spastic paraplegia.