CFTR and cystic fibrosis: Cystic fibrosis (CF) was first identified as a distinct condition in 1938 by Dr Dorothy Anderson, who observed a pattern of cystic fibrosis of the pancreas in patients with a history of respiratory issues, subsequently leading to the identification of cystic fibrosis as a distinct condition.1 CF is a common autosomal recessive congenital disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene responsible for anion transport, predominantly chloride & bicarbonate, across epithelial cell membranes and mucociliary clearance in respiratory airways.2