In a meta-analysis of 12 randomized placebo controlled trials (9 MEK inhibitor monotherapy studies, 1 BRAF inhibitor monotherapy study, and 2 combination therapy studies), MEK inhibitors were associated with a higher risk of reduced LVEF (OR: 3.35; 95% CI: 1.58-7.07) and peripheral edema (OR: 2.87; 95% CI: 1.93-4.27) when compared with placebo.58 The gene discussed is MAP2K7; the disease is Peripheral edema.