ACE and cancer: In 2006, Cardinale et al,17 published a seminal paper reporting the results of a randomized, controlled, open-label study of intervention with the ACE inhibitor enalapril initiated 1 month after completion of high-dose chemotherapy and continued for 1 year in a heterogenous cohort of patients with cancer with evidence of acute myocardial injury, reflected in raised cardiac troponin I concentration (>70 ng/L) at the time of high-dose chemotherapy.