The data of current study has also shown that the ratio of suicide attempters in all MDD patients was 57.47%, and decreased serum IL-8 levels were observed in suicide attempters with drug-free MDD, non-suicide attempters with drug-free MDD, and suicide attempters with SSRIs-medicated MDD in comparison to non-suicide attempters of HCs, respectively. Here, CXCL8 is linked to major depressive disorder.