DGCR8 and schizophrenia: Notably, current evidence from the pathway analysis demonstrated that the genes targeted by the alterant schizophrenia-associated microRNA highly enriched in neural connectivity and synaptic plasticity pathways, such as axon guidance, long-term potentiation, WNT, ErbB and MAP kinase signaling (12) and this corresponds with the deficits of Dgcr8 mice (5).