DGCR8 and schizophrenia: It has been established that individuals with 22q11.2 microdeletions, removing a series of genes including DGCR8, exhibit a spectrum of cognitive deficits and approximately 30% of them develop typical schizophrenia or schizoaffective disorder in adolescence or early adulthood (3), which account for up to 1–2% of sporadic schizophrenia cases (4).