DGCR8 and schizophrenia: Moreover, increased miRNA biogenesis and DGCR8, an RNA binding protein intimately involved in miRNA processing, were observed in the schizophrenia cohort (20) and it was featured in postmortem brain study that DGCR8 was significantly upregulated in the superior temporal gyrus (STG), the dorsolateral prefrontal cortex (DLPFC) (12) and hippocampus (21) which was in line with the elevation of schizophrenia-associated miRNA.