TRPV4 and cardiovascular disorder: Indeed, TRPV4 channels have surfaced as particularly pivotal conduits for dynamic Ca2+ signaling in the endothelium (Bagher et al., 2012; Bubolz et al., 2012; Filosa et al., 2013; Liu et al., 2021) and altered TRPV4 signaling has been implicated in progressive cardiovascular disease (Nishijima et al., 2014; Zhang et al., 2018).