Growing evidence supports involvement of these channels in shear stress and agonist-mediated endothelial signaling, and changes in TRPV4 signaling are linked to disease states including hypertension, diabetes and pulmonary edema (Hartmannsgruber et al., 2007; Mendoza et al., 2010; Sonkusare et al., 2012; Ma et al., 2013; Monaghan et al., 2015; Zhang et al., 2018; Daneva et al., 2021; Rajan et al., 2021). This evidence concerns the gene TRPV4 and hypertensive disorder.