Intriguing, previous observations show a link between enhanced levels of PKC protein and improved survival in colon cancer (Dowling et al., 2016), pancreatic cancer (Baffi et al., 2019), and non-small-cell lung carcinoma (Halvorsen et al., 2020) proposing an overall tumor suppressive function of PKC. Here, PRRT2 is linked to familial pancreatic carcinoma.