The smoothing curve showed that a U-shaped curve association existed between TBiL and the prevalence of PAD in Chinese adults with hypertension (after adjusting for sex, age, BMI, SBP, DBP; smoking status, drinking status, diabetes mellitus, stroke, CHD, Hcy, FPG, TG, LDL-C, AST, ALT, eGFR, antihypertensive drugs, glucose-lowering drugs, lipid-lowering drugs). This evidence concerns the gene GPT and diabetes mellitus.