Furthermore, low adiponectin serum levels, which are inversely related to NAFLD severity, play a vital role in the pathogenesis between NAFLD and subclinical coronary atherosclerosis [37] since it regulates the inflammatory response by inhibiting macrophages and cytokine production, impacting the diseases' manifestation and severity [9]. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatotic liver disease.