Our signature comprising eight GRIPs (TLR1, IFNGR2, CCL25, IL15, CCL8, NLRP6, EMP3, and RTP4) was superior to Lin‘s inflammation signature, an inflammatory response-related signature predicted the 3-year OS of patients with hepatocellular carcinoma with an AUC of 0.705 (59) and other researches' pyroptosis signature (10, 35) at 0.662 to 0.70. The gene discussed is IFNGR2; the disease is hepatocellular carcinoma.