Our signature comprising eight GRIPs (TLR1, IFNGR2, CCL25, IL15, CCL8, NLRP6, EMP3, and RTP4) was superior to Lin‘s inflammation signature, an inflammatory response-related signature predicted the 3-year OS of patients with hepatocellular carcinoma with an AUC of 0.705 (59) and other researches' pyroptosis signature (10, 35) at 0.662 to 0.70. Here, RTP4 is linked to hepatocellular carcinoma.