Ahmadzadeh et al. reported that CD8+ T cells stimulate granulocytes and “produce perforin” or “produce granulocyte colony-stimulating factor and perforin” to kill tumor cells and that melanoma with high CD8+ T cell infiltration is more likely to respond to anti-PD-1/PD-L1 therapy (77). The gene discussed is PRF1; the disease is melanoma.