DEGs were calculated and transcription factor enrichment analysis based on the TRRUST database found that NF-κB and STAT3 were preferentially activated transcription activators in the score-high group (Figure 2B), possibly indicating that increased IFNGR1 and IFNGR2 expression was associated with an alternative activation state of macrophages in the glioma microenvironment. The gene discussed is STAT3; the disease is glioma.