For example, TGF-beta is involved in the inhibition of antigen presentation, the function of antigen-presenting cells, and the activation of T cells (42), COX-2 and PGE2 participate in tumor growth and angiogenesis (43), as well as CCL2, recruits immunosuppressive cells such as regulatory T cells and MDSC (44, 45). The gene discussed is CCL2; the disease is neoplasm.