HDAC5 and chronic kidney disease: We first examined the expression pattern of HDAC IIa in human kidneys using the Nephroseq database.1 In Ju CKD Glom (14), three members of HDAC IIa, including HDAC5, HDAC7, and HDAC9 but expect HDAC4, were all significantly upregulated in glomeruli in human FSGS compared with healthy controls (Figure 1).