STAT4 and urinary bladder cancer: In bladder cancer, the inflamed type demonstrated the highest levels of many immune cell types, including cytotoxic lymphocytes, T cells, and the immune regulators nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) and signal transducer and activator of transcription 4 (STAT4), while the MYC-driven subtypes, including the Myc type and early type, exhibited repressed immune responses and worse prognoses than the inflamed type (31).