PLP1 and leprosy: Regarding neuropathy-related genes, some targets were statistically elevated in nerves from PNL patients, such as HLA-DRB1, APOB, and WNK, while others were downregulated, including HLA-DQB1 and PLP1. Interestingly, HLA-DRB1, previously reported to influence leprosy susceptibility (33), was upregulated 60-times more in leprosy nerves when compared to non-leprosy nerves.