PROS1 and HIV infectious disease: HIV infection has been associated with endothelial damage, liver disease, and increment of predisposing factors for hypercoagulable state such as presence of anti-cardiolipin antibodies and lupus anticoagulant, and deficiencies of protein C, protein S, heparin cofactor II, and antithrombins, which cause activation and consumption of coagulation factors that can affect the PT and APTT value, which might be the possible reason for the high PT and APTT values among HIV-infected individuals [12, 54–56].