TNF and neoplasm: In view of the need for tumor cells to adapt to their high energy demands and uncontrolled growth, tumor therapy targeted at the metabolic pathways required for the survival and growth of tumor cells is also a promising idea.31 T. Habtetsion and his colleagues altered tumor metabolism through CD4 positive T cells, leading to the increase in the oxidative stress dependent tumor necrosis factor (TNF-) and tumor cell death, as shown in Fig. 5.