TP53 and malignant glioma: The EGFR, PI3K/Akt, p53, TGF-dependent apoptotic signaling cascades, Notch and NF-κB pathways were among the most important pathways, while miRNAs played a key role in regulating these pathways, indicating a close relationship with distinct malignant glioma morphologies (Novakova et al., 2009; Zhang et al., 2009; Zhou et al., 2010; Li et al., 2015; Cao et al., 2019; Deng et al., 2020).