UOX has been used to treat hyperuricemia in blood vessels, but the byproduct H2O2 may lead to side effects.33,54 Various ways have been used to solve this problem by using a catalytic cascade of UOX and catalase via diverse nanotechnologies.17–19,55,56 EcN can be a good carrier for these enzymes. The gene discussed is CAT; the disease is hyperuricemia.