It was noteworthy that NRBP2 upregulation in cancer cells significantly decreased the number of tubes formed by HUVECs (oe-NC vs. oe-NRBP2: TPC-1: 0.36 vs. 0.12, p < 0.0001; CAL62: 0.24 vs. 0.09, p = 0.0003) (Figure 3(d)). The gene discussed is NRBP2; the disease is cancer.