The involvement of Paneth cell dysfunction in the pathogenesis of multiple diseases has been widely reported, such as in Crohn’s disease (CD) (11), alcoholic steatohepatitis (28), graft-versus-host disease (GVHD) (29), and irritable bowel syndrome (IBS) (15), etc. The dysfunction of Paneth cells in AP patients and AP mice, manifested by the marked reduction in the number of Paneth cells and the expression of AMPs, was in line with previous findings in rats (30). Here, ADSL is linked to graft versus host disease.