FGF21 and obesity due to melanocortin 4 receptor deficiency: Similar to the patterns observed in the hippocampus, we also found significant negative associations between FGF21 (AUC)35 and CBF (AUC)35 after oral sucrose in the dorsal striatum (Figure 2B) and insula among individuals with healthy weight in both unadjusted and adjusted analyses, but not among individuals with overweight or obesity (Table S6).