TNF and inflammatory bowel disease: As TNF‐α is an important necroptosis inducing cytokine, TNF‐α was elevated in the intestine of Casp8ECko mice (see Fig 2A), and as anti‐TNF‐α treatment is used in IBD patients (Peyrin‐Biroulet et al, 2021), we questioned whether the observed phenotype in Casp8ECko could be due to TNF‐α signaling.