LDLRAP1 and obesity due to melanocortin 4 receptor deficiency: To prove that miR-29a-3p contributes to energy balance control in vivo, we aimed to attenuate Dicer1 depletion-induced obesity in adult CamKCreERT2Dicerfl/fl [13] (further referred to as DicerCKO) mice by injecting a liposomal formulation of locked nucleic acid (LNA)-stabilized mimics [27] of miR-29a-3p into ARH (Tables S1–2 and Figure 1D).