Although overexpression of c-KIT - rather than mutations in its gene - has been reported in a high percentage of small cell lung cancer (SCLC) patients by different groups [116-120], its prognostic relevance remains debatable due to conflicting findings that may be related to the type of tumor specimens used (biopsy or surgical samples), cancer stages, and other variables that still need to be scrutinized. The gene discussed is KIT; the disease is small cell lung carcinoma.