The association between c-KIT (CD117) and EMT is also supported by studies in ovarian cancer cells, where a reduction of CD117+ and CD44+ subpopulation of ovarian CSCs by metformin at low dose led to a significant decrease of Snail2, Twist, and vimentin related to mesenchymal traits, and an increase in expression of the epithelial marker E-cadherin [157]. This evidence concerns the gene KIT and ovarian cancer.