Using experimental models of bone metastasis, we observed de novo expression of c-KIT in intraosseous tumors generated by otherwise c-KIT-negative PCa cell lines, suggesting an induction of c-KIT expression in PCa cells by the bone microenvironment, which was confirmed by co-culture studies of PCa cells and bone marrow-derived cells [127,130]. This evidence concerns the gene KIT and posterior cortical atrophy.