In addition, the expression of Hsp27 in CRC was strongly related with the co-presence of wild-type KRAS and activated phosphoinositide 3-kinases (PI3Ks)/AKT, indicating a possible role of Hsp27 in overcoming PI3K/AKT oncogene-induced senescence in CRC tumors [34]. Here, KRAS is linked to colorectal carcinoma.