They showed that Hsp27 promoted angiogenesis through TLR3-dependent calcium entry and Nf-κB activation in human endothelial cells, leading to subsequent secretion of vascular endothelial growth factor (VEGF), which is the main regulator of cancer angiogenesis, and activation of VEGFR2 and interleukin-8 (IL-8), which are the proangiogenic factors in endothelial cells. The gene discussed is VEGFA; the disease is cancer.