Inconsistent with these reports, in a study of paired human colon adenocarcinoma cell lines, SW480 (primary/pre-metastatic tumor) and SW620 (lymph node metastasis), Zhao et al. showed that, unlike SW620 cells, SW480 cells released Hsp27, indicating Hsp27 expression may be inversely related with the metastatic activity of CRC cells. Here, HSPB1 is linked to metastatic malignant neoplasm in the lymph nodes.