High Wip1 was significantly associated with positive p53, which was significantly associated with low nuclear phospho-p38 only in the patients without lymph node metastasis (p=0.029 and 0.028; Fig. 3A), but no significant association was found in those with lymph node metastasis (Fig. 3B). Here, PPM1D is linked to metastatic malignant neoplasm in the lymph nodes.