In MYCN-related mice models, phosphatidylinositol 3-kinase (PI3K)/mTOR pathway inhibition is reported to destabilize N-Myc and be effective against tumors [34, 35], while other studies have reported that N-Myc could regulate the mTOR pathway in neuroblastoma [36, 37]. The gene discussed is MYCN; the disease is neuroblastoma.