The uroepithelial cells secreted IL-8, IL-6 and IL-1β [23] and the blood serum of IC/BPS patients was shown to have increased expression of pro-inflammatory cytokines and chemokines (IL-1β, IL-6, IL-8) [24], therefore we focused on these cytokines. The gene discussed is IL1B; the disease is Bartsocas-Papas syndrome 1.