GSTM1 and kidney disorder: Notably, reports from several large randomized trials of an increased risk of mortality, thrombotic events, and cardiovascular outcomes in ESA-treated patients when targeted to normalize Hb [15–17] led the Food and Drug Administration and the Kidney Disease: Improving Global Outcomes (KDIGO) group to advise against using ESAs in patients with Hb levels > 10 g/dL [12, 18].