ROC curve analyses indicated that CRP exhibited the highest AUC value when used for the diagnosis of PJI (0.841), followed by the ESR (AUC = 0.850), NLR (AUC = 0.708), GLB levels (AUC = 0.747), and A/G (AUC = 0.779) (Fig. 1). This evidence concerns the gene ESR1 and juvenile polyposis syndrome.