CDK7 and neoplasm: We also found that CSDE1 acts as a connector of RNAPII and CDK7 to regulate the interaction between RNAPII and CDK7, thereby affecting the transcription of Rac1. Therefore, our study identified not only an association between reduced expression of miR-371b-5p and tumor progression in vitro and in vivo but also the role of oncogenic CSDE1 in regulating Rac1 transcription in TNBC cells (Fig. 8F).