NFKB1 and nasopharyngeal carcinoma: Crucial genomic changes, including various loss-of-function mutations in NF-κB negative regulators [7, 8] and recurrent genetic lesions, including loss of the CDKN2A/CDKN2B locus, TP53 mutation, CCND1 amplification, chromatin modification, and mutation in the PI3K signaling pathway [1, 6], promote NPC development and progression.