The similar phenotype was also observed upon SCIN overexpression in NPC cells (P < 0.05, 0.01, or 0.001, Fig. 7E, G, I), indicating that NF-κB signaling is a downstream regulator of the MEX3A-SCIN axis in NPC cells. The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.