To explore the potential effect of GCN5 on cardiac hypertrophy, we established a model of pathological cardiac hypertrophy via TAC surgery; we detected cardiac function using transthoracic echocardiography (Fig. 1A–D) and investigated the remodeling of histology (Supplementary Fig. 1A-B) at 2 and 4 weeks after sham or TAC surgery. The gene discussed is KAT2B; the disease is persistent truncus arteriosus.