YAP1 and small cell lung carcinoma: However, recent SCLC profiling studies of both human tumors and preclinical models (such as SCLC cell lines, genetically engineered mouse models, and patient‐derived xenografts) suggest distinct SCLC subtypes defined by the relative expression of four key transcriptional regulators: ASCL1 (SCLC‐A), NEUROD1 (SCLC‐N), POU2F3 (SCLC‐P), and YAP1 (SCLC‐Y) [4].