CENPF and Stromme syndrome: We speculate that this wide ranges of phenotypes might be dependent on a gene‐dosage effect with biallelic LoF variants resulting in the absence of the protein product being associated with the clinical presentations that include the full spectrum of Strømme syndrome, and missense variants allowing for some degree of residual CENPF protein function being associated with phenotypes that do not include Strømme syndrome‐related internal malformations.