The reactive oxygen species (ROS)‐producing NADPH oxidase (NOX) proteins are important drivers of DM‐induced oxidative stress17 and have been shown to affect AGE accumulation in turn18, and increase the expression of the proinflammatory intercellular adhesion molecule 1 (ICAM‐1) and vascular cell adhesion molecule 1 (VCAM‐1).19, 20, 21. This evidence concerns the gene ICAM1 and diabetes mellitus.