NR4A2 and Alzheimer disease: Energy balance is crucial to neuronal health and glucose is the main source of energy in the brain.[31] Contributions of altered glucose utilization and other metabolic factors to neurodegenerative diseases are well‐documented, especially in the context of AD.[43, 44, 45, 46, 47] Improved glucose utilization and energy generation therefore evolve as further Nurr1‐mediated neuroprotective mechanisms of simvastatin.