UCP2 and nervous system disorder: UCP2 allows metabolic adaptation to change the availability of nutrient utilization, which is critical to the normal survival and development of hippocampal and other brain neurons.[44] The key role of the brain mitochondrial adaptation is to influence neural circuits to support normal and altered adult behavior, which were supported with neuroimaging data from human neonates.[45] Disturbed neurogenic‐to‐gliogenic transition leads to many neurological diseases, including de novo gliomagenesis and hydrocephalus.