No difference was observed in the TLR4-mut-HFD group in either the cortex (Fig. 8D and H) or the hippocampus (Fig. 8O and S) compared to the TLR4-mut ND group in the cortex (Fig. 8C and G) or hippocampus (Fig. 8N and R), suggesting that microglial activation is an indicator of inflammation after MS and it is mitigated by TLR4 mutation (Fig. 8T–V). The gene discussed is TLR4; the disease is myeloid sarcoma.