For colonic epithelial cells (EpCAM+), the population of DiO-positive cells in normal and colitis mice was 6.29% and 7.32%, respectively (Fig. 4B); For dendritic cells (CD11c+), this proportion was 0.103% and 0.096%, respectively (Fig. 4C); As for colonic macrophage cells (CD11b+F4/80+), this proportion in normal and colitis mice was 15.2% and 20.4%, respectively (Fig. 4D). The gene discussed is ITGAX; the disease is colitis.