TmPyP4 (5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine) is widely used as a photosensitizer and a modulator of nucleic acid secondary structur with an inhibitory effect on G-quadruplex formation could increase levels of miR-149 in breast cancer cells, leading to reduction of Zinc Finger And BTB Domain Containing 2 (ZBTB2) expression and attenuation of cell proliferation [22]. This evidence concerns the gene ZBTB2 and breast carcinoma.