Accordingly, levels of the immunostimulatory cytokine IFN-γ [32] significantly rose (Additional file 1: Figure S5a) and immunosuppressive cytokines transforming growth factor β (TGF-β) and interleukin-10 (IL-10) [33, 34] significantly declined (Additional file 1: Figure S5b) in tumor, suggesting that DEXP&A&N remodel tumor microenvironment. This evidence concerns the gene TGFB1 and neoplasm.