Incorporation of Fms-related tyrosine kinase 3 ligand (Flt3L), a major regulator for DC development [17, 18], to the DEXP&A&N regime further augmented the antitumor immunogenicity, elicited long-lived protective T cell memory against tumor re-challenge and resulted in tumor eradication in a majority of mice with established orthotopic HCC tumors. The gene discussed is FLT3LG; the disease is hepatocellular carcinoma.