As shown in Fig. 3, ICAM-1 and CXCL-1 expression increased in AIA rats at the preclinical phase (Fig. 3A, C) and at the onset of arthritis (Fig. 3F, H) while VCAM-1 increased only at the onset of arthritis (Fig. 3B, G). The gene discussed is ICAM1; the disease is Arthritis.