In two different non-small cell lung cancer (NSCLC) models, researchers found that co-delivery of OAd and helper-dependent Ad (HDAd) expressing IL-12 and anti-programmed death-ligand 1 (PD-L1) by mesenchymal stromal cells may both directly destroy tumor spheroid formations in vitro and boost responses of CAR-T cells against orthotopic tumors in vivo. This evidence concerns the gene CD274 and non-small cell lung carcinoma.