CALR and cancer: DAMPs released during ICD comprise chaperones of endoplasmic reticulum (ER) such as heat-shock proteins (HSPs) and calreticulin (CALR) [57], type I interferons (I-IFNs), non-histone chromatin-binding protein HMGB1 [58, 59], ATP [60], annexin A1 (ANXA1) [61], and cancer cell-derived nucleic acids [62].