ERBB2 and head and neck cancer: Moreover, in another study to enhance CAR T-cells activity in a mouse model of head and neck squamous cell carcinoma, oncolytic Ad was equipped with the IL-12 (an immune-stimulatory cytokine) and a PDL1-blocking antibody, combined with HER2/neu (human epidermal growth factor receptor 2)-specific CAR T-cells for the treatment of head and neck cancer.