CXCL11 was transmitted to the specific tumor tissue in this investigation either by subcutaneous administration of a VV equipped with CXCL-11 (VV.CXCL-11) or by overexpression in transferred T cells adoptively transfected with a lentiviral transgene cassette that produced a 4-1BB carrying both anti-mesothelin CAR T-cell and CXCL-11 [166]. This evidence concerns the gene CXCL11 and neoplasm.