Heparins main effects are on the coagulation cascades, mediated through inhibition of factor Xa and thrombin, but it has also been reported heparin-associated reduction in PAI-1 levels in patients with acute coronary syndrome (ACS) patients [27], as well as stimulation of tPA-release form endothelial cells by heparin [28]. The gene discussed is F10; the disease is acute coronary syndrome.