CD274 and cancer: Compared with pan-cancer signatures (INFG.Sig [76], T.cell.inflamed.Sig [76], PDL1.Sig [77], LRRC15.CAF.Sig [78], NLRP3.Sig [79], and Cytotoxic.Sig [80]), Stem.Sig showed best performance in the testing set with an AUC of 0.71, followed by INFG.Sig with an AUC of 0.66 (Fig. 5A).